Lab Research Project Manager, The Centre for Phenogenomics
About the role
About SickKids
Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.
When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.
Don't miss out on the opportunity to work alongside the world's best in paediatric healthcare.
Position Description
Lab Research Project Manager, Model Production Technologies
The Hospital for Sick Children at The Centre for Phenogenomics (TCP)
Position Overview
The Model Production Core at the Centre for Phenogenomics is a highly collaborative, multidisciplinary team dedicated to delivering genetically engineered mouse models to researchers in academia and industry worldwide.
We are seeking a highly skilled, collaborative, and innovative scientist at a senior postdoctoral or early industry career stage who is ready to transition into a role with increasing scientific ownership, platform responsibility, and a clear leadership trajectory. This role is ideal for candidates who have already demonstrated technical independence and sound scientific judgment and who are motivated to contribute to shared research infrastructure.
Reporting to the Director, Research and Technology Development, the Manager will play a hands-on role in model production and technology development. This position is ideal for a candidate who not only excels at the bench, but who also aspires to developing skills in technology strategy, cross-core coordination, and scientific leadership, with the long-term opportunity to advance within the Core.
Key Responsibilities
- Lead and contribute to the development, optimization, validation, and implementation of new and emerging technologies used for genetically engineered rodent model production, in collaboration with the Director.
- Design, troubleshoot, refine and execute experimental workflows for model production pipelines.
- Translate emerging methods from the scientific literature into operationally robust protocols.
- Maintain technical readiness of the molecular biology core, including reagent generation, assay validation, SOP development, and documentation.
- Serve as a scientific and technical resource for colleagues, supporting troubleshooting and protocol improvement.
- Collaborate with internal TCP cores and external platform partners to ensure efficient, high-quality model delivery.
- Contribute to planning, reporting, grant development, and budgeting activities as part of leadership development.
- Actively support continuous improvement, innovation, and staff development.
- Support training, mentorship, and scientific knowledge transfer within the team.
Technical Skills and Expertise
Strong depth in several areas is expected. However, candidates are not required to possess all skills upon entry.
Molecular Biology & Genome Engineering
- Advanced experience with PCR/qPCR, cloning (Gibson, Golden Gate), vector design, assay development, sequence analysis, and reagent quality control.
- Hands-on experience with CRISPR/Cas-based genome engineering such as Cas9 nuclease systems, base editors, or prime editing.
- Experience with CRISPR delivery modalities relevant to model generation, such as microinjection, electroporation, or viral and/or RNP-based delivery.
Genetics & Bioinformatics
- Understanding of mouse genetics, such as knockout, knock-in, and conditional allele strategies and interpretation of genotyping and inheritance patterns.
- Experience with sgRNA and template design, off-target analysis, and interpretation of Sanger sequencing or NGS data.
- Familiarity with bioinformatics tools or pipelines used in sequence analysis and data interpretation.
- Experience with R or other scripting language for data analysis and visualization.
Experimental Mouse Colonies
- Experience supporting or managing experimental mouse colonies, including breeding strategies, genotyping workflows, and allele tracking.
- Familiarity with colony management databases, LIMS, or institutional tracking systems to support accurate record keeping and compliance.
- Understanding of regulatory and ethical frameworks governing animal research.
Embryo Manipulation & Reproductive Technologies
- Hands-on experience with embryo manipulation techniques (microinjection, electroporation, embryo transfer, cryopreservation) OR experience coordinating experiments with specialized embryo manipulation teams.
Qualifications
Required
- PhD in molecular biology, genetics, bioinformatics, or a related discipline.
- '1 year of postdoctoral and/or equivalent industry experience with demonstrated technical independence.
- Proven ability to troubleshoot complex experimental workflows
- Strong organizational skills, meticulous record-keeping, and a commitment to quality and reproducibility.
- Excellent written and verbal communication skills.
- A commitment to understanding and aiding in the pursuit of equity, diversity and inclusion objectives.
Highly Regarded
- Experience working in a core facility or shared research platform.
- Experience mentoring students, trainees, or junior staff.
- Interest in developing expertise in project coordination, platform operations, or scientific leadership.
What You Will Learn in the First 12-14 Months
- End-to-end understanding of genetically engineered mouse model production from design through delivery.
- Application of genome engineering strategies within a service delivery framework.
- Cross-core coordination across molecular, embryo manipulation, phenotyping, and colony management teams.
- Budgeting, reporting, and grant development supporting platform sustainability.
- Leadership fundamentals including mentoring, coaching, and guiding staff.
- Operational considerations to balance innovation, service delivery, and strategic planning within a core facility.
Career Development & Advancement
This role is structured to support long-term career progression beyond a traditional postdoctoral position, offering mentorship, increasing responsibility, and a pathway toward senior scientific and leadership roles within the Centre.
Appointment Terms
This position is offered as an initial two-year contract, with good potential for renewal and advancement based on performance and institutional priorities. Please submit a CV and resume when applying for this position.
Our Commitment to Diversity
SickKids is committed to championing equity, diversity and inclusion in all that we do, fostering an intentionally inclusive and culturally safe environment that reflects the diversity of the patients, families and communities we serve. Learn more about workplace inclusion.
Accessibility & Accommodation
If you require accommodation during the application process, please reach out to our aSKHR team. SickKids can provide access and inclusion supports to eligible candidates to support their full engagement during the interview and selection process as well as to ensure candidates are able to perform their duties once successfully hired. If you are invited for an interview and require accommodation, please let us know at the time of your invitation to interview. Information received related to access, inclusion or accommodation will be addressed confidentially.
How To Apply
Technical difficulties? Email ask.hr@sickkids.ca with a short description of the issues you are experiencing. We will not accept resumes sent to this inbox but we are happy to respond to requests for technical assistance.
Tip: Combine your cover letter and resume into ONE document of 20 pages or less as you cannot upload multiple documents as part of your application.
Every application is reviewed by a human recruiter and all hiring decisions are made by people. In some cases, AI-assisted tools are used to help review applications based on job-related qualifications.
All positions posted on the SickKids Hospital's Careers Site represent current vacancies, unless otherwise posted in the job description.
Not the right fit? Search for Lab Research Project Manager, The Centre for Phenogenomics jobs in Toronto, ON
About The Hospital for Sick Children
The Hospital for Sick Children (SickKids) is recognized as one of the world’s foremost paediatric health-care institutions and is Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally.
Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system.
SickKids is a founding member of Kids Health Alliance, a network of partners working to create a high quality, consistent and coordinated approach to paediatric health care that is centred around children, youth and their families.
SickKids is proud of its vision of Healthier Children. A Better World.™
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Lab Research Project Manager, The Centre for Phenogenomics
About the role
About SickKids
Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built - nor could it be maintained - without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.
When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.
Don't miss out on the opportunity to work alongside the world's best in paediatric healthcare.
Position Description
Lab Research Project Manager, Model Production Technologies
The Hospital for Sick Children at The Centre for Phenogenomics (TCP)
Position Overview
The Model Production Core at the Centre for Phenogenomics is a highly collaborative, multidisciplinary team dedicated to delivering genetically engineered mouse models to researchers in academia and industry worldwide.
We are seeking a highly skilled, collaborative, and innovative scientist at a senior postdoctoral or early industry career stage who is ready to transition into a role with increasing scientific ownership, platform responsibility, and a clear leadership trajectory. This role is ideal for candidates who have already demonstrated technical independence and sound scientific judgment and who are motivated to contribute to shared research infrastructure.
Reporting to the Director, Research and Technology Development, the Manager will play a hands-on role in model production and technology development. This position is ideal for a candidate who not only excels at the bench, but who also aspires to developing skills in technology strategy, cross-core coordination, and scientific leadership, with the long-term opportunity to advance within the Core.
Key Responsibilities
- Lead and contribute to the development, optimization, validation, and implementation of new and emerging technologies used for genetically engineered rodent model production, in collaboration with the Director.
- Design, troubleshoot, refine and execute experimental workflows for model production pipelines.
- Translate emerging methods from the scientific literature into operationally robust protocols.
- Maintain technical readiness of the molecular biology core, including reagent generation, assay validation, SOP development, and documentation.
- Serve as a scientific and technical resource for colleagues, supporting troubleshooting and protocol improvement.
- Collaborate with internal TCP cores and external platform partners to ensure efficient, high-quality model delivery.
- Contribute to planning, reporting, grant development, and budgeting activities as part of leadership development.
- Actively support continuous improvement, innovation, and staff development.
- Support training, mentorship, and scientific knowledge transfer within the team.
Technical Skills and Expertise
Strong depth in several areas is expected. However, candidates are not required to possess all skills upon entry.
Molecular Biology & Genome Engineering
- Advanced experience with PCR/qPCR, cloning (Gibson, Golden Gate), vector design, assay development, sequence analysis, and reagent quality control.
- Hands-on experience with CRISPR/Cas-based genome engineering such as Cas9 nuclease systems, base editors, or prime editing.
- Experience with CRISPR delivery modalities relevant to model generation, such as microinjection, electroporation, or viral and/or RNP-based delivery.
Genetics & Bioinformatics
- Understanding of mouse genetics, such as knockout, knock-in, and conditional allele strategies and interpretation of genotyping and inheritance patterns.
- Experience with sgRNA and template design, off-target analysis, and interpretation of Sanger sequencing or NGS data.
- Familiarity with bioinformatics tools or pipelines used in sequence analysis and data interpretation.
- Experience with R or other scripting language for data analysis and visualization.
Experimental Mouse Colonies
- Experience supporting or managing experimental mouse colonies, including breeding strategies, genotyping workflows, and allele tracking.
- Familiarity with colony management databases, LIMS, or institutional tracking systems to support accurate record keeping and compliance.
- Understanding of regulatory and ethical frameworks governing animal research.
Embryo Manipulation & Reproductive Technologies
- Hands-on experience with embryo manipulation techniques (microinjection, electroporation, embryo transfer, cryopreservation) OR experience coordinating experiments with specialized embryo manipulation teams.
Qualifications
Required
- PhD in molecular biology, genetics, bioinformatics, or a related discipline.
- '1 year of postdoctoral and/or equivalent industry experience with demonstrated technical independence.
- Proven ability to troubleshoot complex experimental workflows
- Strong organizational skills, meticulous record-keeping, and a commitment to quality and reproducibility.
- Excellent written and verbal communication skills.
- A commitment to understanding and aiding in the pursuit of equity, diversity and inclusion objectives.
Highly Regarded
- Experience working in a core facility or shared research platform.
- Experience mentoring students, trainees, or junior staff.
- Interest in developing expertise in project coordination, platform operations, or scientific leadership.
What You Will Learn in the First 12-14 Months
- End-to-end understanding of genetically engineered mouse model production from design through delivery.
- Application of genome engineering strategies within a service delivery framework.
- Cross-core coordination across molecular, embryo manipulation, phenotyping, and colony management teams.
- Budgeting, reporting, and grant development supporting platform sustainability.
- Leadership fundamentals including mentoring, coaching, and guiding staff.
- Operational considerations to balance innovation, service delivery, and strategic planning within a core facility.
Career Development & Advancement
This role is structured to support long-term career progression beyond a traditional postdoctoral position, offering mentorship, increasing responsibility, and a pathway toward senior scientific and leadership roles within the Centre.
Appointment Terms
This position is offered as an initial two-year contract, with good potential for renewal and advancement based on performance and institutional priorities. Please submit a CV and resume when applying for this position.
Our Commitment to Diversity
SickKids is committed to championing equity, diversity and inclusion in all that we do, fostering an intentionally inclusive and culturally safe environment that reflects the diversity of the patients, families and communities we serve. Learn more about workplace inclusion.
Accessibility & Accommodation
If you require accommodation during the application process, please reach out to our aSKHR team. SickKids can provide access and inclusion supports to eligible candidates to support their full engagement during the interview and selection process as well as to ensure candidates are able to perform their duties once successfully hired. If you are invited for an interview and require accommodation, please let us know at the time of your invitation to interview. Information received related to access, inclusion or accommodation will be addressed confidentially.
How To Apply
Technical difficulties? Email ask.hr@sickkids.ca with a short description of the issues you are experiencing. We will not accept resumes sent to this inbox but we are happy to respond to requests for technical assistance.
Tip: Combine your cover letter and resume into ONE document of 20 pages or less as you cannot upload multiple documents as part of your application.
Every application is reviewed by a human recruiter and all hiring decisions are made by people. In some cases, AI-assisted tools are used to help review applications based on job-related qualifications.
All positions posted on the SickKids Hospital's Careers Site represent current vacancies, unless otherwise posted in the job description.
Not the right fit? Search for Lab Research Project Manager, The Centre for Phenogenomics jobs in Toronto, ON
About The Hospital for Sick Children
The Hospital for Sick Children (SickKids) is recognized as one of the world’s foremost paediatric health-care institutions and is Canada’s leading centre dedicated to advancing children’s health through the integration of patient care, research and education. Founded in 1875 and affiliated with the University of Toronto, SickKids is one of Canada’s most research-intensive hospitals and has generated discoveries that have helped children globally.
Its mission is to provide the best in complex and specialized family-centred care; pioneer scientific and clinical advancements; share expertise; foster an academic environment that nurtures health-care professionals; and champion an accessible, comprehensive and sustainable child health system.
SickKids is a founding member of Kids Health Alliance, a network of partners working to create a high quality, consistent and coordinated approach to paediatric health care that is centred around children, youth and their families.
SickKids is proud of its vision of Healthier Children. A Better World.™