Who We Are:
Xenon Pharmaceuticals (NASDAQ: XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy and depression. Our flagship azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. Building upon the positive results and compelling data from our Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our Phase 3 epilepsy program includes multiple clinical trials evaluating azetukalner in patients with focal onset seizures and primary generalized tonic-clonic seizures. In August 2025, we announced the completement of patient recruitment in our Phase 3 X-TOLE2 study and topline data are anticipated in early 2026. We also have multiple Phase 3 azetukalner clinical trials in major depressive disorder (MDD) and bipolar depression (BPD) underway, based on topline data from our Phase 2 “X-NOVA” clinical trial. In addition, we are proud of the leading-edge science coming out of our discovery labs, including early-stage research programs that leverage our extensive ion channel expertise and drug discovery capabilities to identify validated drug targets and develop new product candidates, and have recently initiated Phase 1 studies for our follow-on Kv7 channel opener, XEN1120, and our lead Nav1.7 development candidate, XEN1701, in pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:
We are seeking a Senior Manager, Finance to join our team. This position will be responsible for managing the month-end/quarter-end close processes, preparation of accurate SEC reporting, researching technical accounting issues, managing SOX compliance for our internal processes, assisting with tax compliance and other duties as directed. The Senior Manager, Finance will work closely with other members of the Accounting Operations team and other stakeholders, along with external auditors to ensure accurate reporting and full compliance with all external standards.

This position reports to the Associate Director, Finance and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. This role is a hybrid position, requiring a minimum of 2 days per week in the office.

RESPONSIBILITIES:

• Manage the month-end and quarter-end close processes, preparation of consolidated financial statements and notes in the quarterly 10-Q/Ks, and corresponding working papers and schedules, with a focus on accuracy and timeliness for quarterly external financial reporting.
• Assist with the preparation of other external filings, including Proxy, Prospectuses, etc.
• Research appropriate guidance and prepare technical memos on accounting and reporting issues including equity stock compensation, inventory and revenue recognition, as well as significant transactions and events, or changes to accounting guidance.
• Manage and review the accrual process for Research and Development (R&D) related expenses based on internal and external data.
• Manage and coordinate the interim and annual audit processes with external auditors.
• Review financial analysis prepared by the FP&A team and prepare external MD&A disclosures.
• Manage finance-related systems including Shareworks (stock compensation) and Active Disclosure (SEC financial reporting).
• Manage equity awards records and stock compensation expense calculation in Shareworks.
• Collaborate with the Associate Director, Finance to coordinate with external SOX consultants and external auditors, ensuring efficient execution of SOX testing and appropriate risk management.
• Maintain SOX control documentation, make recommendations and update for changes in processes and controls throughout the year to ensure compliance with SOX standards.
• Manage the updating and redesign of SOX requirements due to future planned migration to a new ERP system.
• Design and implement new processes or participate in projects to streamline processes, as required.
• Serve as a resource to support tax compliance requirements, including the preparation of tax working papers, compilation and calculation of SR&ED/R&D tax credits, and working with outside tax consultants on tax related matters, as required.
• Assist with other financial reporting and accounting duties and/or projects as required.
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.

QUALIFICATIONS:

• Professional designation (CPA) is required, Big Four or large regional CPA firm preferred
• Minimum of 6 years of experience, with at least 2 years of experience in a public company
• Strong accounting knowledge of US GAAP and SOX requirements
• Highly proficient MS Excel skills
• Proven experience building strong relationships with both internal and external stakeholders
• Excellent organizational skills and the ability to manage concurrent deliverables and work effectively in a challenging, milestone-driven environment
• Exceptional interpersonal and communication skills (written and oral); communicates in a clear, concise and organized manner; listens and works collaboratively with others to obtain information
• Strong attention to detail, self-motivated and proven ability to take ownership of tasks and ability to drive projects from start to finish
• Demonstrated high level of integrity and ethics
• Experience working with Great Plains or other ERPs is an asset
• Experience in the biotech industry is an asset

The base salary range for this role is $116,300 to $147,100 CAD; we will consider above this range for exceptional candidates. Base salary is determined by a combination of factors including, but not limited to, education and other qualifications, years of relevant experience, and internal equity.

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

As part of our hiring process, Xenon conducts background checks for finalist candidates. The types of checks conducted will vary depending on the relevance to the position.

US positions only: Xenon Pharmaceuticals USA Inc. participates in the E-Verify program in all states in which we hire. Learn more about the E-Verify program here.

To apply for this position, click Apply Now to complete the application. We thank all applicants for their interest; however, due to the volume of applicants, only those chosen for interview will be contacted.