Technology Platforms and Research Infrastructure - On-site

About the IRCM

The Montreal Clinical Research Institute (IRCM) is a world-class biomedical research center that puts science to work for health. The work of our teams contributes to major advances in research. We provide an environment where scientific rigor and collaboration drive the advancement of knowledge.

What you’ll love

• Contribute to work that has a tangible impact on health and research.

• Thrive in a rigorous, collaborative, and supportive environment.

• Take part in challenging projects and continuous improvement initiatives.

Job Overview

We are looking for a passionate manager to lead the development and operations of the RNA Therapeutics Platform at the Sidney-Altman Hub at the Montreal Clinical Research Institute (IRCM).

You will play a central role in the day-to-day management of operations and the execution of activities, ensuring a harmonious workflow and fostering collaboration between multidisciplinary teams. This position offers a unique opportunity to contribute to cutting-edge research on RNA therapies and to stimulate innovation in RNA biology.

Responsibilities

1. Project management and execution:

Manage the platform’s service offerings and support the development of projects by the platform’s clients (researchers from academia and industry) in therapeutic RNA, ensuring that milestones and objectives are met.

Carry out laboratory work in collaboration with the technical team, including:

Design of oligonucleotides, RNA sequences and vectors.

Synthesis and purification of DNA vector.

In vitro RNA synthesis, purification and quality control of RNA.

Synthesis of oligonucleotides (ASO, siRNA, sgRNA) with or without modified nucleotides, purification, quality control, lyophilization.

Formulation of nanolipid particles and RNA encapsulation, quality control monitoring.

Screening in cell culture test dose-response effects.

Develop and optimize experimental procedures.

Train the technical team.

Plan and carry out technical development projects to improve procedures, implement new approaches and keep the service offering at the cutting-edge.

Develop and maintain a complete project plan, including timelines, deliverables and resource allocation.

Contribute to the development of the business model and service offering of the Sidney-Altman Hub in therapeutic RNA.

1. Operational and Budget Management:

Oversee the day-to-day operations of the ARN platform and its installation.

Coordinate workflow, resolve issues and implement improvements.

Manage internal and external client relationships.

Manage and optimize the allocation of resources, including equipment and materials.

Collaborate with finance management to track expenses and optimize profitability.

Organize the work and supervise the platform team.

1. Quality Assurance:

Establish and ensure quality control measures to ensure the highest standards in RNA, oligonucleotide and nanolipid particle synthesis and purification processes, screening, cell culture assays, and in vivo functional assays.

1. Collaboration and Communication:

Foster a collaborative and communicative environment among team members, researchers and external collaborators.

Regularly communicate project updates, challenges and achievements to stakeholders.

1. Regulatory Compliance:

Stay up to date with relevant techniques, regulations and industry standards related tRNA-based therapeutic approaches.

Ensure that the RNA platform complies with all applicable guidelines and regulations.

What You Bring to the Table

Essential Requirements

Hold a PhD degree in molecular biology, biochemistry or a related field or a Master’s degree (MSc) with equivalent laboratory experience.

Demonstrate solid expertise in RNA biology, particularly in methodologies and techniques for the synthesis and purification of RNA, oligonucleotides and nanolipid particles.

Knowledge of the steps of the nucleic acid production chain.

Desired Skills

Have proven experience in project management in a research or biotechnology context.

Demonstrate strong organizational and leadership skills, with the ability to multitask and prioritize effectively.

Master advanced communication and interpersonal skills to foster collaboration between diverse teams.

Have a good knowledge of regulatory requirements in the field of molecular biology.

Key Information

• Schedule: Full-time (35 hours/week).

• Position type: Permanent.

• Salary: Between $99 008 and $124 706 (based on experience and current policies).

Benefits

• 20 days of vacation after one year.

• 10 days of personal or sick leave.

• Additional time off during the holiday season.

• Defined-benefit pension plan (RREGOP).

• Group insurance.

• Access to telemedicine for you and your family.

• Employee Assistance Program (EAP).

• Facilities for cyclists (secure parking and showers).

• Accessible location in the heart of Montreal.

• Collaborative and respectful work environment.

• Opportunities for professional development.

Submit Your Application

Submit your application (resume) by clicking “Apply.”

To learn more about the IRCM: https://www.ircm.qc.ca

Selection Process

Selected candidates will be contacted for an interview. Background checks may be conducted depending on the nature of the position.

The IRCM values diversity, equity, and inclusion. We encourage applications from people of all backgrounds.

Accommodations may be provided upon request at any stage of the recruitment process. To request accommodations, please indicate this in the “Is there anything else you'd like to tell us about yourself?” section of the application form.