Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting, and continue to advance an early-stage pipeline of novel therapeutic candidates. In 2025, we initiated Phase 1 trials for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7). Nav1.7 and Kv7 are important pain targets, and data from these Phase 1 studies are expected in 2026 to support Phase 2 proof-of-concept studies in acute pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

About the Role:

We are seeking aNetwork Systems Engineer/ Senior Network Systems Engineerto join our team. As a Network System Engineer/Senior Network Systems Engineer, you will lead key activities to oversee and manage the company’s networking infrastructure, ensuring seamless connectivity and robust performance across all systems. You will manage complex network environments, maintain enterprise certificate systems, and support essential applications and identity services. You’ll also craft technical documentation, collaborate with business units to deploy innovative solutions, and partner with IT Security to uphold high standards and address vulnerabilities. This position will be part of a dynamic environment and team.

This position reports to the Director, Infrastructure & Operations, and will be based out of Vancouver, BC, Canada. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

RESPONSIBILITIES:

• Manage networking environment including Cisco switches, Palo Alto firewalls, HPE ClearPass, and Meraki Wi-Fi.
• Manage Microsoft Azure environment including virtual machines, networking, Azure Files, enterprise applications, and storage accounts.
• Manage enterprise certificate architecture.
• Support Citrix NetScaler.
• Support Microsoft Active Directory and Entra environments.
• Develop documentation including Standard Operating Procedures, Knowledge base articles, and System Design Specifications.
• Collaborate with IT business partners to evaluate and implement software solutions.
• Collaborate with IT Security to evolve the network environment to enhance performance, reliability, and security, remediate vulnerabilities and adhere to best practices within the IT infrastructure.
• Submit and present IT change controls, participate in IT problem management, and manage IT incidents.
• Troubleshoot a wide range of hardware and software issues, in consultation with other team members when necessary.
• Effectively manage and leverage managed service provider (MSP) resources.
• Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
• Some international travel may be required.
• Other duties as assigned.

QUALIFICATIONS:

• Degree or diploma in computer science or related discipline, with 5 or more years of experience. Experience in the life sciences industry is preferred.
• Familiar with Computer Systems Assurance and/or GxP Systems Validation.
• Hands-on experience with ITIL processes and best practices.
• Takes initiative and the ability to troubleshoot technical problems, works well under pressure, and learn quickly.
• Ability to problem-solve while being resourceful, flexible, and calm.
• Excellent customer service skills and professional demeanor.
• Strong organizational skills with the ability to prioritize multiple ongoing projects and daily tasks.
• Excellent written and oral communication skills with the ability to explain technical concepts to non-technical audiences.

TECHNICAL SKILL SET:

• Network design and implementation
• TCP/IP protocols and subnetting
• Routing and switching (Cisco)
• Firewall setup and management (Palo Alto)
• Wireless networking technologies (Meraki)
• Network security practices and tools (e.g., 802.1x)
• Monitoring and troubleshooting network performance
• VPN configuration and management
• Load balancing and failover solutions
• Familiarity with network management software and tools (e.g., Wireshark)
• Azure cloud networking
• Documentation and diagramming of network infrastructure
• Citrix NetScaler
• Scripting (PowerShell, bash)

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.

Compensation Range: CA$102K - CA$141.4K