Principal Clinical Scientist

Principal Clinical Scientist (AI Training) About The Role What if your years of clinical trial expertise could directly shape how AI understands, evaluates, and reasons about medical evidence? We're looking for a Principal Clinical Scientist to bring senior-level rigor to AI-driven research workflows — ensuring that the clinical data powering next-generation AI systems meets the same standards expected in real-world regulatory submissions. This is a fully remote, flexible contract role designed for experienced clinical scientists who want to work at the intersection of medicine and frontier AI. Organization: Alignerr Type: Hourly Contract Location: Remote Commitment: 10–40 hours/week What You'll Do Design and review clinical trial protocols used to generate high-quality, regulatory-grade datasets for AI training Interpret and audit clinical trial results for accuracy, consistency, and alignment with regulatory standards Evaluate AI-generated clinical analyses for scientific soundness and compliance with FDA, EMA, or equivalent agency expectations Provide expert, structured feedback that directly improves how AI models reason about clinical trial data, outcomes, and evidence Work independently and asynchronously — fully on your own schedule Who You Are Senior-level experience designing clinical trial protocols intended for regulatory submission Deep expertise interpreting clinical data for regulatory agencies such as the FDA, EMA, or equivalent Strong background in clinical research methodology, biostatistics, or translational science Naturally rigorous and detail-oriented — you hold AI outputs to the same standards you'd apply to a real submission Clear and confident communicator who can translate complex clinical concepts into actionable feedback Nice to Have Prior experience with data annotation, data quality review, or AI evaluation systems Background in pharmacovigilance, medical affairs, or clinical operations Familiarity with AI tools or content evaluation workflows Experience working across multiple therapeutic areas or regulatory jurisdictions Why Join Us Work directly on frontier AI systems that are reshaping clinical and biomedical research Influence how AI understands, evaluates, and applies real-world clinical evidence Fully remote and flexible — work when and where it suits you Freelance autonomy with the structure of meaningful, expert-level work Collaborate with world-leading AI research teams and labs on high-impact projects Potential for ongoing work and contract extension as new projects launch

Design and review clinical trial protocols to generate high-quality datasets for AI training. Evaluate AI-generated clinical analyses for scientific soundness and compliance with regulatory standards from agencies like the FDA and EMA.

Requires senior-level experience in designing clinical trial protocols for regulatory submissions and deep expertise in interpreting clinical data. Candidates must be detail-oriented communicators with a strong background in clinical research methodology or biostatistics.

• Clinical OperationsPreferred

Identified from the job description. Confirm important requirements above.

• Clinical Trial Protocol Design
• Regulatory Submission
• Clinical Data Interpretation
• FDA Compliance
• EMA Compliance
• Clinical Research Methodology
• Biostatistics
• Translational Science
• Data Annotation
• AI Evaluation
• Pharmacovigilance
• Medical Affairs
• Clinical Operations
• Scientific Auditing
• Data Quality Review

• Science & Research
• Healthcare
• Technology
• Data & Analytics
• Software

Minimum experience

10+ years

Posting language

English

Working hours

40 hours per week

Seniority

Mid-Senior level