Scientist I or II, Proteomics

Job summary

Operate, maintain, and troubleshoot Thermo Scientific mass spectrometers while designing and conducting proteomics experiments for drug discovery, including target identification, target engagement, and drug-response studies. Lead proteomics projects, analyze and interpret data, optimize workflows, and guide junior staff in collaboration with interdisciplinary teams.

Job details

Position: Scientist I or II, Proteomics Reports to: Associate Director, Proteomics Employment Term: Permanent, Full-time Location: Mississauga, ON Start Date: Immediate About Dalriada Drug Discovery Inc. Founded in 2017, Dalriada is a leading Canadian drug discovery organization specialized in small molecule therapies. Purposely built as an agile, co-located and uniquely integrated drug discovery partner, Dalriada accelerates the discovery and development journey of high value new small molecule therapeutics from concept to IND. Our unique Turn-Key™ operational model offers the global biotechnology industry a full suite of drug discovery, preclinical development, intellectual property, and business expertise to manage and execute tailored R&D programs. Visit us at www.dalriadatx.com. About the Role The Scientist I or II, Proteomics is instrumental in shaping and driving Dalriada's proteomics projects, leveraging deep expertise to advance our understanding of complex biological systems. The role designs and performs proteomic experiments and mentors scientific staff while collaborating with interdisciplinary stakeholders, contributing significantly to the development of innovative therapeutic solutions. Key Responsibilities Perform day-to-day maintenance, operation, and troubleshooting of Thermo Scientific mass spectrometers to ensure reliable instrument performance and minimize downtime. Lead and manage proteomics projects to support drug discovery programs, collaborating closely with medicinal chemists, biologists, and other stakeholders. Design and execute proteomic experiments to identify and validate drug targets, investigate target engagement, and assess drug response in cellular models. Utilize advanced mass spectrometry techniques, such as quantitative proteomics and chemoproteomics, to profile protein expression, protein-drug interactions, and protein-protein interactions. Develop and optimize sample preparation protocols to ensure compatibility with downstream proteomics analyses and maximize the coverage of the proteome. Apply bioinformatics tools and statistical methods to analyze proteomic data and identify biomarkers, pathways, and networks relevant to drug discovery. Provide scientific leadership and guidance to junior scientists and research associates involved in proteomics experiments, fostering a collaborative and innovative work environment. Stay abreast of emerging technologies, methodologies, and trends in proteomics and drug discovery, and evaluate their potential application in our research projects. Qualifications PhD or MSc in Analytical Chemistry, Biochemistry, Chemical Biology, or related discipline. Post-graduate lab experience in drug discovery settings is desirable but not necessary. Deep knowledge and proven experience in proteomics and mass spectrometry. Hands-on expertise in operation and maintenance of Thermo Fisher Orbitrap mass spectrometers. Experience in discovery proteomics (e.g., TMT & DIA) and targeted proteomics (PRM, SRM). Knowledge of the application of proteomics in advanced drug discovery approaches such as covalent programs and targeted protein degradation is desired. Experience in key proteomics workflows including chemoproteomics, affinity purification-mass spectrometry, and proximity labeling are definite assets. Working knowledge of statistics and experience in a scripting language (e.g., R, Python) is desired. Proficiency with open-source and vendor-specific proteomic software (e.g., DiaNN, Proteome Discoverer, Skyline, FragPipe). Ability to analyze, interpret, and present scientific data, and propose next steps in experimental design and project strategy. Driven by scientific excellence and cost/process efficiency. Offers timely results through sound judgment and scientific knowledge. Thinks critically and generates creative solutions to challenging scientific questions. Approaches work with an entrepreneurial mindset, working independently and seeking professional input when necessary. Superior communication skills (written and verbal) and interpersonal skills. Fast learner, flexible, and innovative, able to work collaboratively within cross-functional teams. Able to manage multiple projects simultaneously and meet aggressive project timelines. Why This Role? Make a direct impact – Contribute intellectually to the creation of better medicines, designing and evaluating new drug molecules across multiple therapeutic areas. Work with innovative clients – Interact directly with management teams of innovative pharmaceutical and VC-backed biotech companies from across Canada, the US and Europe. Cutting-edge science – Actively conduct and advance cutting-edge proteomics in a state-of-the-art R&D facility. Interdisciplinary collaboration – Collaborate with Dalriada's expert drug discovery scientists in medicinal & computational chemistry, cell & molecular biology, biophysics & biochemistry, ADME and proteomics. Access to senior leadership – Work closely with Dalriada senior leadership and an executive team of experienced drug discovery scientists, innovators and industry executives. Grow every day – Learn new things every day in a fast-paced, stimulating, values-based company committed to driving growth, delivering solutions, being accountable and creative. If you are interested in this opportunity, please submit your resume to careers@dalriadatx.com referencing Scientist, Proteomics in the subject line. This position is open to applicants legally authorized to work in Canada. Dalriada Drug Discovery Inc. is an equal opportunity employer, and we are committed to achieving accessibility by providing accommodation for people with disabilities during our hiring process. Accommodation is available on request for qualified candidates during the recruitment process. All employment is conditional upon completing and obtaining a satisfactory background check which may include educational, employment, references, and criminal records.

What you’ll do

Operate, maintain, and troubleshoot Thermo Scientific mass spectrometers while designing and conducting proteomics experiments for drug discovery, including target identification, target engagement, and drug-response studies. Lead proteomics projects, analyze and interpret data, optimize workflows, and guide junior staff in collaboration with interdisciplinary teams.

Requirements

Requires a PhD or MSc in analytical chemistry, biochemistry, chemical biology, or a related discipline, along with deep proteomics and mass spectrometry experience and hands-on expertise with Thermo Fisher Orbitrap instruments. Experience with discovery and targeted proteomics, proteomics software, and data analysis is expected; scripting, advanced drug discovery workflows, and post-graduate drug discovery lab experience are desirable or assets.

Listed skills

• Python · Preferred
• Cross-Functional Collaboration · Preferred

Other relevant skills

Identified from the job description. Confirm important requirements above.

• Proteomics
• Mass Spectrometry
• Thermo Fisher Orbitrap Operation and Maintenance
• Discovery Proteomics
• Targeted Proteomics
• Chemoproteomics
• Sample Preparation
• Bioinformatics
• Statistical Analysis
• R
• Python
• Proteomic Data Analysis
• Project Leadership
• Scientific Communication
• Cross-Functional Collaboration

Job areas

• Science & Research
• Healthcare
• Data & Analytics
• Management & Leadership