Senior Mass Spectrometry Scientist

Vancouver, BC
On-site
Posted Aug 17, 2026
1 position

Opens an external site

Employment type: Full-time
Experience level: Senior · 5+ years
Minimum education: Master’s degree
Posting language: English
Working hours: 40 hours per week

Job summary

You will lead the development, validation, and execution of clinical multi-omic assays while overseeing laboratory operations and instrumentation. Additionally, you will mentor junior staff and collaborate with cross-functional teams to integrate mass spectrometry data into the company's platform.

Job details

Molecular You is redefining what it means to know your health. Our precision multi-omic platform generates deep molecular profiles that help people and their clinicians take meaningful, proactive action. As a Senior Mass Spectrometry Scientist, you will be a technical cornerstone of our analytical laboratory—developing, validating, performing, and overseeing clinical multi-omic assays that underpin the absolute quantification workflows at the heart of our clinical operations. This is a high-impact opportunity for a scientist who combines deep technical expertise with the discipline of a regulated clinical environment and is energized by translating rigorous analytical science into real-world health impact. You will own assay development from conception through ISO-compliant deployment, solve complex instrumentation and shape next-generation MS capabilities, and mentor junior scientists in best practices. Key Responsibilities Assay Development & Absolute Quantification Develop, optimize, and implement proprietary MRM-MS assays for targeted absolute quantification of proteins, lipids, metabolites, and other analytes across complex biological matrices (including plasma, serum, and potentially others). Execute full method validation packages in accordance with FDA Bioanalytical Method Validation guidance, CLIA and ISO 15189 frameworks. Develop, update, and maintain SOPs that support robust, reproducible, and audit-ready laboratory workflows. Develop technical and training transfer packages that enable partner laboratories to accurately and reproducibly run our assays in a clinical laboratory environment. Develop new MS-based technologies for integration into Molecular You's clinical multi-omic assay workflow. Instrumentation & Troubleshooting Serve as a subject matter expert for LC-MS/MS platforms (e.g., Agilent, Sciex, Thermo, Waters), including source optimization, ion-pair selection, chromatographic troubleshooting, and scheduled MRM configuration. Lead systematic troubleshooting of assay failures, matrix interference, ion suppression, and carryover issues, escalating findings and implementing permanent corrective actions. Maintain instrument qualification (IQ/OQ/PQ) records and coordinate preventative maintenance schedules with vendors in accordance with laboratory SOPs. Clinical Laboratory Operations Operate within a regulated clinical laboratory (ISO 15189 or equivalent) environment, maintaining strict adherence to SOPs, chain-of-custody protocols, and sample integrity requirements. Partner with the laboratory director and QA/QC team to prepare, maintain, and execute documentation required for ISO accreditation, proficiency testing, and external audits. Ensure all assay workflows are audit-ready, including instrument logs, reagent traceability, QC charts, and deviation records. Data Analysis & Scientific Communication Perform and review quantitative data analysis using software platforms such as MassHunter, Skyline, or equivalent, ensuring accurate peak integration and batch review. Author high-quality technical reports, SOPs, and method transfer documents; present findings to cross-functional stakeholders including bioinformatics, product, and medical teams. Contribute to peer-reviewed publications and support intellectual property activities as applicable. Mentorship & Collaboration Mentor and coach junior scientists and laboratory technicians in MRM-MS principles, laboratory operations, and quantitative method development. Collaborate with bioinformaticians, data scientists, and software engineers to integrate MS data streams into Molecular You's broader multi-omic platform. Support procurement and capital equipment decisions for next-generation mass spectrometry infrastructure. Qualifications Required PhD. in Analytical Chemistry, Biochemistry, Proteomics, Metabolomics, or a closely related field; or M.Sc. with 5+ years of directly relevant industry experience. 5+ years of hands-on experience developing and validating quantitative MRM-MS assays in a professional laboratory setting. Demonstrated expertise in absolute quantification by LC-MS/MS using stable isotope-labeled internal standards and external calibration curves. Deep familiarity with at least one major LC-MS/MS vendor platform (Agilent, Sciex, Thermo Scientific, or Waters). Expertise in operating LC-MS/MS systems and using associated acquisition, processing, and method-development software. Proven ability to independently troubleshoot complex analytical problems across chromatography, ionization, and detection. Experience working with a laboratory information management system (LIMS). Preferred Experience in a multi-omic or systems biology context, with exposure to proteomics, metabolomics, or lipidomics at a clinical or translational scale. Experience with clinical laboratory setup, launch, or scale-up. Familiarity with Skyline or similar open-source MRM data management and analysis tools. Direct experience working in or supporting an ISO 15189-accredited or equivalent clinical or regulated analytical laboratory. Prior involvement in ISO accreditation drives, external laboratory audits, or regulatory submissions Experience with automated sample preparation platforms (e.g., Hamilton, Tecan) and their integration with MS workflows. Comfort working in a fast-paced, cross-functional environment where scientific rigor and operational agility are equally valued. A builder mindset: you enjoy creating robust analytical systems, improving how a laboratory operates, and collaborating across disciplines to turn complex science into scalable clinical impact. What We Offer Molecular You offers a collaborative, science-first environment where your work has a direct impact on how people understand and act on their health. You will join a team working at the leading edge of health and longevity, using multi-omic science to help move healthcare toward earlier, more precise, and more proactive action. In addition to competitive compensation and benefits, you will have access to a state-of-the-art analytical facility, a multidisciplinary team of scientists and engineers, and the opportunity to help build something genuinely new in precision health. Competitive salary commensurate with experience and qualifications. Extended health, dental, and vision benefits. Equity participation in a growth-stage company. Continuous learning budget and conference travel support. Flexible work environment with a collaborative, inclusive culture. Maybe add something on be at the leading edge in health and longevity?

What you’ll do

Requirements

The role requires a PhD in a relevant scientific field or an M.Sc. with at least 5 years of industry experience in quantitative MRM-MS assay development. Candidates must possess deep expertise in LC-MS/MS platforms and experience working within regulated clinical laboratory environments.