Research Associate II, Protein Engineering

Job summary

Perform protein purification and analytical characterization of protein-based molecules while designing experiments for multispecific antibody therapeutics. Maintain an organized laboratory environment and document methods through standard operating procedures.

Job details

What You'll Do * Perform protein purification and analytical characterization of various protein-based molecules. * Design, plan and execute experiments to characterize multispecific antibody-based therapeutics through developability assays. * May assist in affinity measurements to screen protein therapeutics. * Troubleshoot methods, suggest improvements and develop new technologies for project advancement. * Write standard operating procedures for methods requiring significant technical understanding, data manipulation and calculations. * Analyze data, draw conclusions and participate in cross-departmental activities. * Maintain a clean, organized and operational lab. * Conduct all activities in accordance with scientific standards, OH&S regulations and established policies and practices. * Actively work to foster an environment of effective and collaborative working relationships across the organization. What You'll Bring * A BSc in a relevant scientific discipline (biochemistry, immunology, etc.) and a minimum of 2-3 years related experience or a Master’s degree with an equivalent combination of education and experience. * Hands-on experience in protein purification (affinity, protein A/G/L, IEX, and SEC). * Experience in protein analytical techniques (e.g. PAGE, CE-SDS, ELISA, MSD, UPLC-SEC). * Knowledge in therapeutics developability assays (AC-SINS, non-specific ELISA, HIC). * Understanding of different affinity measurement methods (e.g. SPR, BLI, KinExA, on-cell binding). * Ability to work collaboratively as a member of cross-functional team. * Good organizational skills and the ability to work effectively in a high paced, fast changing environment. * Ability to present data at team and inter-departmental meetings. Total Rewards We offer a comprehensive total rewards package, which includes competitive salaries, generous benefits, an outstanding work environment, and excellent opportunities for professional growth. We regularly benchmark our compensation against leading biotechnology companies in our geographies. The base salary range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position in the location for which the job is posted and does not include bonus, equity, or benefits. Within the range, individual pay is determined by a variety of factors and the salary offered may vary depending on the successful candidate’s location and qualifications (including, but not limited to, job-related knowledge, education, training, skills, and experience). Our total rewards package that includes: * Industry leading vacation and paid time off * Exceptional medical, dental and vision benefits by country * Zymelife health and wellness benefits * Matching RRSP / 401K / Pension program * Employee Share Purchase Program * Employee Equity Program * Paid time off to volunteer in your community This role is not eligible for relocation or immigration support. All qualified applicants will receive consideration for employment without regard to race, colour, religion, sex, sexual orientation, gender identity, national origin or disability. NOTE TO AGENCIES: Zymeworks values our relationships with our recruiting partners. We only accept resumes from those partners who have been contracted with us. Zymeworks is not responsible for any fees related to resumes that are unsolicited or are received without contract.

What you’ll do

Perform protein purification and analytical characterization of protein-based molecules while designing experiments for multispecific antibody therapeutics. Maintain an organized laboratory environment and document methods through standard operating procedures.

Requirements

Requires a BSc in a relevant scientific discipline with 2-3 years of experience or a Master's degree. Candidates must have hands-on experience in protein purification and analytical techniques such as PAGE, ELISA, and UPLC-SEC.

Benefits

• Vacation
• Paid time off
• Medical benefits
• Dental benefits
• Vision benefits
• Health and wellness benefits
• Matching RRSP
• 401K
• Pension program
• Employee share purchase program
• Employee equity program
• Volunteer time off

Listed skills

• Analytical · Preferred
• Organized · Preferred
• procedures. · Preferred
• Time · Preferred
• discipline · Preferred
• Health · Preferred
• collaborative · Preferred
• Technical · Preferred
• Training · Preferred
• Organization · Preferred
• Attention to detail · Preferred

Other relevant skills

Identified from the job description. Confirm important requirements above.

• Protein purification
• Analytical characterization
• Multispecific antibody therapeutics
• Developability assays
• Affinity measurements
• PAGE
• CE-SDS
• ELISA
• MSD
• UPLC-SEC
• AC-SINS
• HIC
• SPR
• BLI
• KinExA
• Organizational Skills
• Time Off Management
• Analytical Techniques
• Biochemical Assays
• Biochemistry
• Biotechnology
• Immunology
• Data Manipulation
• Enzyme-Linked Immunosorbent (ELISA) Assay
• Standard Operating Procedure
• Protein Purification
• Troubleshooting (Problem Solving)
• Print Binding

Job areas

• Science & Research
• Engineering
• Healthcare
• Engineering Research Associate
• Biochemist
• Biologists, Botanists, Zoologists and Related Professionals
• Biochemists and Biophysicists

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